And I wouldn't mind all that much. Sure it would be awkward at first, but it's something you just get used to.
The Uchiha Clan is basically all incest. That's why it's called a clan! And just because Sasuke and Itachi's mom didn't have the Sharingan doesn't mean she isn't an Uchiha. Not all members have the Sharingan if I recall correctly. And I'm not 100% positive, but I don't think females carry the Sharingan either.